Dylan Phythian has been ruled out for the season following an ACL injury.
It comes as a major blow to the Knights with the fullback touted as mainstay for 2017.
It is unknown who will take the reins at the back with star Dane Gagai an option.
The Knights were strong in their 26-22 Round 1 loss to the Warriors at the weekend.
They host the Titans on Saturday who fell 32-18 to the Roosters in a dismal display.
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