Griffin was told by the club that he would be replaced at the end of this season.

The 51-year-old decided to leave immediately, with assistant Cameron Ciraldo in charge for the rest of 2018.

It has been reported that some senior players at the Panthers were unhappy with Griffin taking the reins.

The former Brisbane coach joined the club in 2016. Griffin had a 58% win percentage at Penrith with 41 victories and 30 losses from 71 matches.

The club tonight confirmed his exit and Panthers CEO Brian Fletcher added: "There has been much speculation and rumours about the club and head coach Anthony Griffin over the last few weeks.

"After discussions with Anthony Griffin it is time to end that speculation. By mutual agreement, the club and Anthony have agreed to part ways, effective immediately.

"Anthony departs the club after much success, having taken the Panthers to the finals in the last two years and leaves the club on track for another finals appearance in 2018.

"We would like to thank Anthony for his service to Panthers and wish him well for the future."